The innovation of RESILIA tissue

Unlike mechanical valves, tissue valves can wear out faster.^1,2 Build-up of calcium on the leaflets is the main reason a tissue valve may break down¹ meaning that you could need a second operation to replace the tissue valve. This has led Edwards Lifesciences to develop RESILIA tissue with special integrity preservation technology that will potentially allow the valve to last longer.^3,4

What is the INSPIRIS RESILIA valve?

The INSPIRIS RESILIA aortic valve is a type of tissue valve containing RESILIA tissue. RESILIA tissue is bovine (cow) heart tissue that has been preserved with a unique Edwards technology, which is designed to reduce calcium build up and is expected to make the tissue more durable than previous generation tissue valves.^3,5

How can the INSPIRIS RESILIA valve help?

Your doctors will work with you to decide if the INSPIRIS RESILIA valve is right for you.
However some of the benefits include:

1. Reduces calcium build-up

RESILIA tissue has demonstrated significantly less calcium build-up.³ Here you can see how RESILIA tissue (left) has less build-up of calcium on the valve leaflets than a non-RESILIA tissue valve (right).³

2. Designed for future valve replacements

If you need another replacement valve in the future, INSPIRIS RESILIA valve allows a new valve to be placed inside.⁴

3. Blood thinners are not needed with tissue valves

The INSPIRIS RESILIA aortic valve typically will not require you to take long-term blood thinners.⁶ This means that if you lead an active lifestyle, you won’t need to stop your normal activities. It also means that you won’t need to monitor the impact your blood thinner is having on you, or watch how your food could impact its effect.

At Edwards Lifesciences, we are dedicated to providing innovative solutions to patients with cardiovascular disease

We are the global leader in patient-focused medical innovations for structural heart disease. Driven by a passion to help patients, the company collaborates with the world’s leading clinicians and researchers to address unmet healthcare needs, working to improve patient outcomes and enhance lives.

Learn more about how you can prepare for your procedure

References

Bourguignon T, et al. Ann Thorac Surg. 2015;99:831‒7.
Tillquist MN & Maddox TM. Patient Prefer Adherence. 2011;5:91–9.
Flameng W, et al. J Thorac Cardiovasc Surg. 2015;149:340–5.
Edwards Lifesciences. INSPIRIS RESILIA Aortic Valve, Model 11500A, Instructions for use.
Edwards LifeSciences. Capping bioprosthetic tissue to reduce calcification. EP3453409A1, European Patent Office (2013). Available at: https://data.epo.org/publication-server/document?iDocId=5871989&iFormat=0. Accessed June 2024.
Vahanian A, et al. Eur Heart J. 2022;43:561–632.

No clinical data are available that evaluate the long-term impact of RESILIA tissue in patients. Additional clinical data for up to 10 years of follow-up are being collected to monitor the long-term safety and performance of RESILIA tissue.

Medical device for professional use

For a listing of indications, contraindications, precautions, warnings, and potential adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).