- MR ≥ 3+ (alternate MAC Registry eligibility below)
- Refer to Clinical Study Protocol for alternate MAC Registry eligibility
- NYHA functional class ≥ II
- Commercially available surgical or transcatheter treatment options are deemed unsuitable due to clinical, anatomic, or technical considerations as determined by the Heart Team
- Optimized heart failure management based on subject characteristics and applicable guidelines, and stable for at least 30 days prior to enrollment (Failed TEER Registry exception)
§ Refer to Clinical Study Protocol for full inclusion and exclusion criteria